What is his eyes soften when he looks at me?

As an AI language model I don't have enough context to understand who "he" refers to.

But generally speaking, when someone's eyes soften when they look at another person, it can be a sign of affection, attraction or tenderness. It indicates that they feel comfortable and safe around the person and that they have positive emotions towards them. Softening of the eyes might mean that the person is relaxing and not feeling stressed or tense. It is a subtle non-verbal cue that can convey a lot of emotions and feelings. Softening of the eyes can also create intimacy and help build a stronger connection between two people.